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For Mayo scientist, spinal-injury research is personal posted Monday, 03 December 2018
In September, Peter Grahn and his Mayo colleagues published a globally recognized breakthrough: using electrical stimulation and therapy exercises to help a paralyzed man walk the approximate length of a football field. Peter Grahn has faced the same question for a dozen years since he dived as a reckless teen into a southwest Minnesota lake, slammed headfirst into the shallow bottom, and floated — face down and motionless — on the surface...
Category: Clinical Trials


Immune cells could hold key to therapies for spinal cord injuries posted Thursday, 08 November 2018
Fresh insights into how zebrafish repair their damaged nerve connections could aid the development of therapies for people with spinal cord injuries. Scientists have found the immune system plays a key role in helping zebrafish nerve cells to regenerate after injury. The findings offer clues for developing treatments that could one day help people to regain movement after spinal cord injury. Large immune cells called macrophages are vital for the fish to repair damaged connections, the study found. These cells usually help the body to fight off infections but they also play a key role in wound healing.
Category: Clinical Trials


Paraplegic patients walk again with spinal cord implants posted Wednesday, 07 November 2018
Three patients with severe spinal cord injuries are walking again, thanks to a wireless implant which delivers electrical stimulation to the spinal cord. A team based at the Swiss Federal Institute of Technology (EPFL) surgically implanted spinal cord stimulators in the patients, with the aim of activating the spinal cord via an electrical pulse.
Category: Clinical Trials


Epidural stimulation leads to recovery of cardiovascular function in spinal-cord-injured posted Tuesday, 18 September 2018
For the first time since 2009, Stefanie Putnam is able to prepare -- and eat -- meals for herself, put the vest on her service dog, Kaz, and drive herself to activities with her horse without losing consciousness or gasping for breath. "My whole life has opened up for me again!" Putnam said. A C4 spinal cord injury in 2009 left Putnam paralyzed from the neck down and suffering from chronic low blood pressure. She relied on medication and tight corsets to maintain her blood pressure, but she still passed out five or six times a day...
Category: Clinical Trials


New Method to Create Human Neural Stem Cells Can Regenerate Spine in Rats, Study Shows posted Tuesday, 18 September 2018
Human spinal cord neural stem cells (NSC), created using an innovative method, were seen to regenerate functional neurons in the damaged tissue of rats with spinal injuries, according to researchers. Their study, “Generation and post-injury integration of human spinal cord neural stem cells,” was published in the journal Nature Methods. Spinal cord NSC were already known to have great potential to regenerate damaged spinal cords and re-establish the neural circuitry. However, these cells had never been created in the lab (in vitro)…
Category: Clinical Trials


University of Minnesota Researchers Develop 3D Printed Device to Treat Spinal Cord Injuries posted Wednesday, 15 August 2018
In the United States, 285,000 people are currently suffering from spinal cord injuries. Around 17,000 new spinal cord injuries are recorded every year. However, there are no good or precise treatments to help patients regain functions or alleviate pain. This could change, however, following the outline of research recently published in scientific journal Advanced Functional Materials. A collaboration between engineers and medical researchers from the University of Minnesota has resulted in a 3D printed device which may alleviate pain and help regain functions of muscles, bowels and bladder for patients with long-term spinal cord injuries…
Category: Clinical Trials


Created Line of Spinal Cord Neural Stem Cells Shows Diverse Promise posted Tuesday, 14 August 2018
Researchers at University of California San Diego School of Medicine report that they have successfully created spinal cord neural stem cells (NSCs) from human pluripotent stem cells (hPSCs) that differentiate into a diverse population of cells capable of dispersing throughout the spinal cord and can be maintained for long periods of time...
Category: Clinical Trials


New study offers hope of recovery from spinal cord injury posted Monday, 13 August 2018
Spinal cord injury or damage causes permanent changes in strength, sensation and other body functions. Hope of recuperation is slim to none. Now a new Tel Aviv University study finds the intravenous injection of a potent enzyme, just hours after an accident, has the potential to diminish a cascade of pathological events responsible for neuronal death, such as inflammation and scarring...
Category: Clinical Trials


BioArctic Receives Regulatory Approval in Finland for a Clinical Study in Patients With Complete Spinal Cord Injury posted Thursday, 12 July 2018
STOCKHOLM, July 10, 2018 /PRNewswire/ -- BioArctic AB (publ) (Nasdaq Stockholm: BIOA B) announced today that the company has received approval by Fimea, the Finnish Medicines Agency, and Valvira, the Finnish authority for medical device, as well as the local ethics committee for inclusion of Finnish patients in BioArctic's ongoing clinical Phase 1/2 study with SC0806. The candidate product is a combination of a medical device (implant) and a medicinal product (FGF1) for patients with complete spinal cord injury. This approval means that BioArctic has received approvals in all the countries planned to participate in the study, i.e. Sweden, Estonia, Norway and now Finland...
Category: Clinical Trials


Researchers repair acute spinal cord injury in monkeys posted Wednesday, 06 June 2018
Spinal cord injuries are among the most severe and difficult-to-treat medical conditions, usually resulting in permanent disability including loss of muscle function, sensation and autonomic functions. Medical research is now on the cusp of treating severe spinal cord injuries by inducing the repair of spinal nerves, and scientists have made strides in recent years with rodents and primates...
Category: Clinical Trials

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